Dopamine Buffering Capacity Imaging: A Pharmacodynamic fMRI Method for Staging Parkinson Disease
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چکیده
منابع مشابه
Endogenous calcium buffering capacity of substantia nigral dopamine neurons.
Dopamine (DA)-containing cells from the substantia nigra pars compacta (SNc) play a major role in the initiation of movement. Loss of these cells results in Parkinson's disease (PD). Changes in intracellular calcium ion concentration ([Ca(2+)](i)) elicit several events in DA cells, including spike afterhyperpolarizations (AHPs) and subthreshold oscillations underlying autonomous firing. Continu...
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42 43 Dopamine (DA) containing cells from the substantia nigra pars compacta (SNc) play a 44 major role in the initiation of movement. Loss of these cells results in Parkinson’s 45 disease (PD). Changes in [Ca]i elicit several events in DA cells, including spike 46 afterhyperpolarizations (AHPs) and subthreshold oscillations underlying autonomous 47 firing. Continuous Ca load due to Ca-dependen...
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ژورنال
عنوان ژورنال: Frontiers in Neurology
سال: 2020
ISSN: 1664-2295
DOI: 10.3389/fneur.2020.00370